Article

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

2026-01-07

Abstract excerpt

Astrocytes are increasingly recognized as key players in neurodegeneration 1–3 , yet the molecular mechanisms by which they drive disease remain elusive. Here, we uncover a fundamental pathway in which reactive astrocytes fuel neurodegeneration in α-synucleinopathies—including Dementia with Lewy bodies and Parkinson’s disease dementia—by acidifying the brain’s extracellular environment. We demonstrate that both h...

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Literature Corpus work: 498b0ee2-e52b-550c-abd2-6efe7efad42d
DOI: 10.64898/2026.01.06.697893

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