Article

<i>Mycobacterium tuberculosis</i>-dependent Monocyte Expression Quantitative Trait Loci and Tuberculosis Pathogenesis

2023-08-29

Abstract excerpt

The heterogeneity of outcomes after Mycobacterium tuberculosis (Mtb) exposure is a conundrum associated with millennia of host-pathogen co-evolution. We hypothesized that human myeloid cells contain genetically encoded, Mtb-specific responses that regulate critical steps in tuberculosis (TB) pathogenesis. We mapped genome-wide expression quantitative trait loci (eQTLs) in Mtb-infected monocytes with RNAseq from 80...

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Literature Corpus work: 4ca01aee-bfe5-5213-82f1-90a8bbdd4965
DOI: 10.1101/2023.08.28.23294698

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