Article

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

2024-06-29

Abstract excerpt

The tuberculin skin test (TST) is a cutaneous delayed hypersensitivity reaction to antigen from Mycobacterium tuberculosis (Mtb). We provide the first single cell sequencing characterisation of the human TST reaction, based on skin suction blisters induced at the site of the TST on day 2 in 31 individuals. Integrated single cell RNA and TCR sequencing showed the immune response to be dominated by T cells, with sm...

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Literature Corpus work: 038119f3-96db-5db8-9989-201ec9febf4e
DOI: 10.1101/2024.06.25.600676

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