Mapping cell migrations and fates in a gastruloid model to the human primitive streak

Abstract excerpt

Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS). This is possible because differing levels of BMP, WNT, and NODAL leads to self-organization of gastruloids into homogenous subpopulations of endoderm and mesoderm, and...

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