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Article

A Case for Revisiting Nodal Signaling in Human Pluripotent Stem Cells

10 May 2021

Abstract excerpt

Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri-implantation epiblast in the mouse embryo and subsequently acts to specify mesendodermal fate at the time of gastrulation and, later, left-right asymmetry. Maintenance of human pluripotent stem cells (hPSCs) in vitro is...

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PMID: 33932319
DOI: 10.1002/stem.3383

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