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Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

8 Apr 2022

Abstract excerpt

Human primordial germ cells (hPGCs) form around the time of implantation and are the precursors of eggs and sperm. Many aspects of hPGC specification remain poorly understood because of the inaccessibility of the early postimplantation human embryo for study. Here, we show that micropatterned human pluripotent stem cells (hPSCs) treated with BMP4 give rise to hPGC-like cells (hPGCLC) and use these as a...

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PMID: 35394424
DOI: 10.7554/elife.72811

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