Article

High-confidence structural predictions of extrachromosomal DNA with ecDNAInspector

2025-12-02

Abstract excerpt

Extrachromosomal DNA (ecDNA) are circularized genomic elements that reside outside canonical chromosomes. ecDNA amplify oncogene copy number, enhance chromatin accessibility, and act as mobile enhancers through cis- and trans-regulatory interactions, collectively boosting oncogene expression. ecDNA has been implicated in tumor progression, intratumoral heterogeneity, and poor patient prognosis. Despite various lin...

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Literature Corpus work: 68a3071b-5506-5f9f-8f7e-4c03c9cdd0ad
DOI: 10.64898/2025.12.01.691649

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