Article

ILC1-derived TGFβ1 drives intestinal remodelling

2020-04-22

Abstract excerpt

Organoids can shed light on the dynamic interplay between complex tissues and rare cell types within a controlled microenvironment. Here, we developed gut organoid co-cultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines. We demonstrate for the first time that murine and human ILC1 secrete TGFβ1, driving expansion of CD44v6 + epithelial crypts. ILC1 a...

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Identifiers and source

Literature Corpus work: 7e358f99-c9c6-5537-a5c8-e6df21ac08ac
DOI: 10.1101/2020.04.20.051805

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