Article

Human intestinal organoids with an autologous tissue-resident immune compartment

2023-10-06

Abstract excerpt

The intimate relationship between the epithelium and the immune system is crucial for maintaining tissue homeostasis, with perturbations in epithelial-immune interactions linked to autoimmune disease and cancer. Whereas stem cell-derived organoids are powerful models of tissue-specific epithelial function, these structures lack tissue-resident immune cells that are essential for capturing organ-level processes. We...

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Literature Corpus work: 812de80f-df73-523c-acab-f19835b01611
DOI: 10.1101/2023.10.04.560810

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