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Modeling host-microbe interactions in immunocompetent engineered human gut tissues

2025-05-07

Abstract excerpt

The intestinal mucosal barrier contains microbial organisms within the lumen while preserving the ability to absorb nutrients. Dietary, microbial, and other exposures shaped human barrier evolution and continue to impact disease susceptibility. Here, we established engineered barrier models of the human small intestine and colon composed of a multilineage epithelium, mucus layer, accessible microbial compartment a...

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Identifiers and source

Literature Corpus work
4a19fc6d-3fd7-5666-b9b1-5082d0317831
DOI
10.1101/2025.05.02.651468
Open publication

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Modeling host-microbe interactions in immunocompetent engineered human gut tissuesDOI 10.1101/2025.05.02.651468
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