Article

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors

2024-07-16

Abstract excerpt

Fibroblasts play critical roles in regulating cellular relationships during tissue homeostasis, immunity, and tumor biology at multiple sites. However, tools to perturb fibroblasts at just one site in vivo are limited, restricting our understanding of how these cellular relationships develop on a local level. We optimized local gene editing of fibroblasts in multiple mouse tumor models to investigate how locally r...

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Literature Corpus work: fc64b158-afa4-5fa5-9b80-7e3f2b8ac4a3
DOI: 10.1101/2024.07.11.603114

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