Article

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

2024-02-07

Abstract excerpt

The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti-to pro-inflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of IFNγ-exposure to reprogram intestinal epithelia and thereby directly modulate lymphocyte responses. IFNγ treatment of organoids led to transcriptiona...

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Literature Corpus work: 942d9cec-772e-5f2b-a915-5f01985ad7ed
DOI: 10.1101/2024.02.03.578580

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