Article

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

2018-04-11

Abstract excerpt

<h4>Background</h4> The extent to which changes in gene expression can influence cardiovascular disease risk across different tissue types has not yet been systematically explored. We have developed an analytical framework that integrates tissue-specific gene expression, Mendelian randomization and multiple-trait colocalization to develop functional mechanistic insight into the causal pathway from genetic variant...

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Literature Corpus work: 7e26069b-5b9b-54ec-84f2-323df3d30790
DOI: 10.1101/298687

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