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Article

Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian Randomization approaches

2023-10-31

Abstract excerpt

<h4>Background</h4> Mendelian randomization (MR) leverages genetic variants as instrumental variables to determine causal relationships in epidemiology. However, challenges persist due to heterogeneity arising from horizontal pleiotropy. On the other hand, exploration of the biological underpinnings of such heterogeneity across variants can enhance our understanding of disease mechanisms and inform therapeutic str...

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Literature Corpus work
622fa359-8fbf-5c6e-98f0-70091025d6a5
DOI
10.1101/2023.10.31.23297593
Open publication

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Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian Randomization approachesDOI 10.1101/2023.10.31.23297593
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