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Article

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.

American journal of human genetics - 5 Oct 2017

Richardson Tom G, Zheng Jie, Davey Smith George, Timpson Nicholas J, Gaunt Tom R, Relton Caroline L, Hemani Gibran

Abstract excerpt

The extent to which genetic influences on cardiovascular disease risk are mediated by changes in DNA methylation levels has not been systematically explored. We developed an analytical framework that integrates genetic fine mapping and Mendelian randomization with epigenome-wide association studies to evaluate the causal relationships between methylation levels and 14 cardiovascular disease traits. We identified...

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Identifiers

PMID: 28985495
DOI: 10.1016/j.ajhg.2017.09.003
PMCID: PMC5630190

Genes

ADCY3
ADIPOQ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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