Article

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

2019-02-28

Abstract excerpt

<h4>Background</h4> Developing insight into tissue-specific transcriptional mechanisms can help improve our understanding of how genetic variants exert their effects on complex traits and disease. By applying the principles of Mendelian randomization, we have undertaken a systematic analysis to evaluate transcriptome-wide associations between gene expression across 48 different tissue types and 395 complex traits...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4456e25-03c3-5a3e-9ccf-bd2223e0d3f9
DOI: 10.1101/563379

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenomeDOI 10.1101/563379Read

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.Semantic proximity Read

A multi-tissue mendelian randomization method based on eQTL data for mapping tissue-specific disease genes.Semantic proximity Read

Prioritizing putative influential genes in early life cardiovascular disease susceptibility by applying tissue-specific Mendelian randomizationSemantic proximity Read

Multi-tissue integrated Mendelian randomization method identifies disease risk genes.Semantic proximity Read

The GTEx Consortium atlas of genetic regulatory effects across human tissuesSemantic proximity Read

Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization.Semantic proximity Read

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation.Semantic proximity Read

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traitsSemantic proximity Read

CATaN maps gene regulatory programs that shape genetic risk across complex diseasesSemantic proximity Read

PrediXcan: Trait Mapping Using Human Transcriptome RegulationSemantic proximity Read

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptomeSemantic proximity Read