Article
Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau
2018-03-19
Abstract excerpt
Alzheimer’s and Parkinson’s disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). We recently found that TRIM28 regulates the levels and toxicity of α-Syn and tau (Rousseaux et al., 2016), however, how TRIM28 regulates α-Syn and whether its chronic inhibition later in life is safe remained unkno...
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Identifiers and source
- Literature Corpus work
- 7e1a39f3-096d-599c-8ede-7930d6a2fd44
- DOI
- 10.1101/284984