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The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi

24 Mar 2020

Abstract excerpt

Although the malfunction of HtrA2/Omi leads to Parkinson's disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indicated that HtrA2/Omi degraded oligomeric α-Syn specifically without affecting monomers. Transgenic Drosophila...

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PMID: 32210343
DOI: 10.1038/s41598-020-62309-z

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