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TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice

2026-08-04

Abstract excerpt

Biological sex is a major determinant of Alzheimer’s disease prevalence, yet the molecular mechanisms underlying sex-specific vulnerability remain largely unknown. Metabotropic glutamate receptor 5 (mGluR5) functions as a co-receptor for β-amyloid (Aβ42) oligomer/cellular prion protein (PrP C )-mediated pathogenic signaling in males but not females, establishing a sex-dimorphic node in β-amyloid pathophysiology w...

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Literature Corpus work
324add17-c35f-51bf-be14-15320ad40b39
DOI
10.64898/2026.07.30.741783
Open publication

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