Article
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2010
Greten-Harrison Becket, Polydoro Manuela, Morimoto-Tomita Megumi, Diao Ling, Williams Andrew M, Nie Esther H, Makani Sachin, Tian Ning, Castillo Pablo E, Buchman Vladimir L, Chandra Sreeganga S
Abstract excerpt
Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, α-, β-, and γ-synuclein. α-Synuclein has been the focus of intense attention since mutations in it were identified as a cause for familial Parkinson's disease. Despite their disease relevance, the normal physiological function of synucleins has remained elusive. To address this, we generated and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.