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Article

Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila.

Neurobiology of aging - 1 Jul 2018

Zhang Shiqing, Feng Ruili, Li Yanhui, Gan Linhua, Zhou Fangfang, Meng Shiquan, Li Qian, Wen Tieqiao

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disease associated with the progressive loss of dopaminergic neurons in the substantia nigra. Proteinaceous depositions of alpha-synuclein (α-syn) and its mutations, A30P and A53T, are one important characteristic of PD. However, little is known about their aggregation and degradation mechanisms. Dendritic cell factor 1 (DCF1) is a membrane protein that plays...

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PMID: 29649746
DOI: 10.1016/j.neurobiolaging.2018.03.010

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