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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease

17 May 2024

Abstract excerpt

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by preferential neuronal loss in the striatum. The mechanism underlying striatal selective neurodegeneration remains unclear, making it difficult to develop effective treatments for HD. In the brains of nonhuman primates, we examined the expression of Huntingtin ( HTT ), the gene responsible for HD. We found that HTT...

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PMID: 38758800
DOI: 10.1126/sciadv.adl2036

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TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s diseasePMID 38758800Read ↗

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