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Article

Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau

27 Aug 2022

Abstract excerpt

Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative disorders. Here we develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enable age-dependent quantitative measurement of central nervous system synapse loss and axonal degeneration, in addition to effects upon lifespan, to facilitate...

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PMID: 36030267
DOI: 10.1038/s41467-022-32683-5

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