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Article

SUMOylation in α-Synuclein Homeostasis and Pathology

25 Jun 2020

Abstract excerpt

The accumulation and aggregation of α-synuclein are central to Parkinson's disease (PD), yet the molecular mechanisms responsible for these events are not fully understood. Post-translational modifications of α-synuclein regulate several of its properties, including degradation, interaction with proteins and membranes, aggregation and toxicity. SUMOylation is a post-translational modification involved in various...

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PMID: 32670048
DOI: 10.3389/fnagi.2020.00167

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