Article

Oligomeric α-synuclein-specific degradation by HtrA2/Omi to bestow a neuroprotective function

2018-11-14

Abstract excerpt

Although the malfunction of HtrA2/Omi leads to Parkinson’s disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indicated that HtrA2/Omi degraded oligomeric α-Syn specifically without affecting monomers. Transgenic Drosophila melano...

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Literature Corpus work: 60087cac-c5fd-53cf-99dc-972e4f7afef7
DOI: 10.1101/468967

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