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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.

Cell metabolism - 7 Nov 2023

Xue Dongxiang, Narisu Narisu, Taylor D Leland, Zhang Meili, Grenko Caleb, Taylor Henry J, Yan Tingfen, Tang Xuming, Sinha Neelam, Zhu Jiajun, Vandana J Jeya, Nok Chong Angie Chi, Lee Angela, Mansell Erin C, Swift Amy J, Erdos Michael R, Zhong Aaron, Bonnycastle Lori L, Zhou Ting, Chen Shuibing, Collins Francis S

Abstract excerpt

Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the functional roles of many loci remain unexplored. Here, we engineered isogenic knockout human embryonic stem cell lines for 20 genes associated with T2D risk. We examined the impacts of each knockout on β cell differentiation, functions, and survival. We generated gene expression and chromatin accessibility profiles on β...

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Identifiers

PMID: 37858332
DOI: 10.1016/j.cmet.2023.09.013
PMCID: PMC10841752

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