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Article

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.

Cell reports - 23 May 2017

Guo Min, Zhang Tuo, Dong Xue, Xiang Jenny Zhaoying, Lei Minxiang, Evans Todd, Graumann Johannes, Chen Shuibing

Abstract excerpt

Genome-wide association studies (GWASs) have identified many disease-associated variant alleles, but understanding whether and how different genes/loci interact requires a platform for probing how the variant alleles act mechanistically. Isogenic mutant human embryonic stem cells (hESCs) provide an unlimited resource to derive and study human disease-relevant cells. Here, we focused on CDKAL1, linked by GWASs to...

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Source

Identifiers

PMID: 28538172
DOI: 10.1016/j.celrep.2017.04.070

Genes

CDKAL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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