Article

CFTR mutation leads to intrinsic dysfunction in neutrophils from people with Cystic Fibrosis

2025-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Cystic fibrosis ( CF ), a common genetic disease, is caused by a defective CF-transmembrane conductance regulator ( CFTR ). People with CF ( pwCF ) are prone to develop infections by opportunistic pathogens, including Burkholderia cenocepacia , leading to chronic inflammation and lung function loss. Neutrophils, the most abundant cells in the chronically inflamed lungs of pwCF, release granu...

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Literature Corpus work: 7e07a58e-dcbc-58f9-8d1f-a56361161ea2
DOI: 10.1101/2025.06.08.656500

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