Article
Impact of CFTR Modulators on the Impaired Function of Phagocytes in Cystic Fibrosis Lung Disease.
International journal of molecular sciences - 17 Oct 2022
Meoli Aniello, Eickmeier Olaf, Pisi Giovanna, Fainardi Valentina, Zielen Stefan, Esposito Susanna
Abstract excerpt
Cystic fibrosis (CF), the most common genetically inherited disease in Caucasian populations, is a multi-systemic life-threatening autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In 2012, the arrival of CFTR modulators (potentiators, correctors, amplifiers, stabilizers, and read-through agents) revolutionized the therapeutic approach to CF....
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