Article
Inhibiting CFTR through inh-172 in primary neutrophils reveals CFTR-specific functional defects.
Scientific reports - 28 Dec 2024
Da Silva Cunha Ana Lúcia, Blanter Marfa, Renders Janne, Gouwy Mieke, Lorent Natalie, Boon Mieke, Struyf Sofie, Carlon Marianne S
Abstract excerpt
The lungs of people with cystic fibrosis (PwCF) are characterized by recurrent bacterial infections and inflammation. Infections in cystic fibrosis (CF) are left unresolved despite excessive neutrophil infiltration. The role of CFTR in neutrophils is not fully understood. In this study, we aimed to assess which antimicrobial functions are directly impaired by loss of CFTR function in neutrophils. In order to do...
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