The Challenges of Detecting Neutrophil CFTR.

Abstract excerpt

BACKGROUND: Cystic fibrosis (CF) is a hereditary disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The major causes of morbidity and mortality in CF are related to lung disease, involving neutrophil-dominated lung inflammation. SUMMARY: Whether the altered inflammatory response of neutrophils in patients with CF is an intrinsic defect due to a lack of CFTR...

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