Article
CFTR modulators exert subset-specific phenotype remodeling on circulating neutrophils in cystic fibrosis.
ImmunoHorizons - 10 Jul 2026
Chable de la Héronnière François, Dhôte Théo, de Oliveira Formiga Rodrigo, Regard Lucile, Saraceni-Tasso Giovanni, Andrieu Muriel, Many Souganya, Da Silva Jennifer, Pène Frédéric, Martin Clémence, Ladjemi Maha Zohra, Burgel Pierre-Régis, Witko-Sarsat Véronique
Abstract excerpt
A key aspect of cystic fibrosis pathophysiology is the significant role played by neutrophils, central to the inflammatory response in cystic fibrosis airways. Neutrophil-dominated inflammation greatly influences clinical outcomes, including airway damage and lung function decline. People with cystic fibrosis have an increase in circulating neutrophils that exhibit numerous functional and phenotypic...
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