Article

Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex

2025-02-21

Abstract excerpt

<h4>ABSTRACT</h4> The human cortex undergoes extensive epigenetic remodelling during development, although the precise temporal and cell-type-specific dynamics of DNA methylation remain incompletely understood. In this study, we profiled genome-wide DNA methylation across human cortex tissue from donors aged 6 post-conception weeks (pcw) to 108 years of age. We observed widespread, developmentally regulated, chan...

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Literature Corpus work: 7df6f910-7a48-5940-a5f1-3de114315c50
DOI: 10.1101/2025.02.21.639467

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