Article

Optimised fluorescence-activated nuclei sorting for epigenomic analysis of cortical cell types

2025-12-23

Abstract excerpt

Increased understanding of the functional complexity of the genome has led to growing recognition of the role of non-sequence-based regulatory variation in disorders of the human central nervous system. Most genomic analyses of the brain are limited by the use of bulk tissue, which comprises a heterogeneous mix of different neural cell types with distinct epigenetic profiles, thereby limiting the ability to attrib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfbbbb49-03c2-5e49-be93-8539e5a5300b
DOI: 10.64898/2025.12.22.695789

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimised fluorescence-activated nuclei sorting for epigenomic analysis of cortical cell typesDOI 10.64898/2025.12.22.695789Read

Cell Type-Specific Chromatin Accessibility Analysis in the Mouse and Human BrainSemantic proximity Read

Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortexSemantic proximity Read

Integrative single-cell analysis by transcriptional and epigenetic states in human adult brainSemantic proximity Read

An epigenome atlas of neural progenitors within the embryonic mouse forebrainSemantic proximity Read

Schizophrenia-associated DNA methylation differences in the cortex are neuron-specificSemantic proximity Read

PU.1-driven enrichment enables microglia profiling from frozen brain tissue using the high-throughput Smart-seq3xpress methodSemantic proximity Read

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brainSemantic proximity Read

Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programsSemantic proximity Read

Transcriptomic diversity of cell types across the adult human brainSemantic proximity Read

PEDIA-BRAIN: A single nuclei multiomic encyclopedia of the human pons provides a resource for normal development and disease vulnerabilitySemantic proximity Read

Single-cell analysis of prenatal and postnatal human cortical developmentSemantic proximity Read

NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia TelangiectasiaSemantic proximity Read