Article

Cell type-specific effects of age and sex on human cortical neurons

2023-11-15

Abstract excerpt

<h4>Summary</h4> Excitatory and inhibitory neurons establish specialized identities early in life through cell type-specific patterns of epigenetic regulation and gene expression. Although cell types are largely stable throughout the lifespan, altered transcriptional and epigenetic regulation may contribute to cognitive changes with advanced age. Using single-nucleus multiomic DNA methylation and transcriptome se...

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Literature Corpus work: 6e946937-2971-5fd6-97f4-f7faf3fa5936
DOI: 10.1101/2023.11.11.566717

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