Article

ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancer

2020-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Uncovering mechanisms responsible for the heterogeneous clinical features of this disease is an essential step toward developing improved and more specific therapeutic approaches. Here, we sought to identify transcriptional regulators of aggressive PDAC growth through in vivo CRISPR screening of epigenetic and transcr...

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Literature Corpus work: 7de8ca66-3a64-5e7d-b636-b602c3af7c0a
DOI: 10.1101/2020.05.23.112839

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