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MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

2 Jan 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid cancers; thus, identifying more effective therapies is a major unmet need. In this study, we characterized the super-enhancer (SE) landscape of human PDAC to identify drivers of the disease that might be targetable. This analysis revealed MICAL2 as an SE-associated gene in human PDAC, which encodes the flavin monooxygenase enzyme that...

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PMID: 39745352
DOI: 10.1158/0008-5472.can-24-0744

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