Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma

18 Jan 2023

Abstract excerpt

Pancreatic cancer is characterized by extensive resistance to conventional therapies, making clinical management a challenge. Here we map the epigenetic dependencies of cancer stem cells, cells that preferentially evade therapy and drive progression, and identify SWI/SNF complex member SMARCD3 as a regulator of pancreatic cancer cells. Although SWI/SNF subunits often act as tumor suppressors, we show that SMARCD3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Pancreatic and Hepatic Oncology Research
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36653361
DOI: 10.1038/s41467-023-35796-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinomaPMID 36653361Read ↗

Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer ProgressionSemantic proximity Read ↗

ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancerSemantic proximity Read ↗

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.Semantic proximity Read ↗

Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

The RNA‐binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

The Key Role of COA6 in Pancreatic Ductal Adenocarcinoma: Metabolic Reprogramming and Regulation of the Immune MicroenvironmentSemantic proximity Read ↗

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissueSemantic proximity Read ↗

The chromatin remodeler SMARCD3 regulates cell cycle progression and its expression predicts survival outcome in ER+ breast cancerSemantic proximity Read ↗

The biological role of metabolic reprogramming in pancreatic cancerSemantic proximity Read ↗

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumorsSemantic proximity Read ↗

An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancerSemantic proximity Read ↗

SMARCA4 supports the oncogenic landscape of <i>KRAS</i> -driven lung tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.