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Article

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.

Cancer metastasis reviews - 1 Dec 2021

Andersen Henriette Berg, Ialchina Renata, Pedersen Stine Falsig, Czaplinska Dominika

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers globally with a mortality rate exceeding 95% and very limited therapeutic options. A hallmark of PDAC is its acidic tumor microenvironment, further characterized by excessive fibrosis and depletion of oxygen and nutrients due to poor vascularity. The combination of PDAC driver mutations and adaptation to this hostile environment drives...

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PMID: 34855109
DOI: 10.1007/s10555-021-10004-4

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