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Integrative genomic identification of therapeutic targets for pancreatic cancer

22 Aug 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, and new therapeutic strategies are urgently needed. Here, we conduct an integrative, genome-scale examination of genetic dependencies and cell surface targets using CRISPR-Cas screening and multi-omic data, including single-nucleus and spatial transcriptomic data from patient tumors. We systematically identify clinically tractable and biomarker-linked...

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PMID: 40848256
DOI: 10.1016/j.celrep.2025.116191

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