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Article

Oncogenic KRAS triggers metabolic reprogramming in pancreatic ductal adenocarcinoma

14 Nov 2022

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely high lethality rate. Oncogenic KRAS activation has been proven to be a key driver of PDAC initiation and progression. There is increasing evidence that PDAC cells undergo extensive metabolic reprogramming to adapt to their extreme energy and biomass demands. Cell-intrinsic factors, such as KRAS mutations, are able to...

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Identifiers

PMID: 38130635
DOI: 10.2478/jtim-2022-0022

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