Article

β-Cell Obligation in α-Cell Glucagon Response to Low Glucose

2026-04-15

Abstract excerpt

<title>Abstract</title> <p>Type 1 diabetes (T1D) destroys insulin-producing pancreatic β-cells, causing chronic hyperglycemia. Patients are also vulnerable to life-threatening hypoglycemia, driven largely by defective α-cell glucagon secretion, yet the mechanisms underlying this counterregulatory failure remain poorly understood. Using human pseudoislets from non-diabetic donors and complementary mouse models, we...

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Literature Corpus work: 97358ffd-ea94-5043-896c-ccd27dc5d31c
DOI: 10.21203/rs.3.rs-9039050/v1

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