Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.

doi:10.1002/jmv.24763

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Article

Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.

Journal of medical virology - 1 Jul 2017

Murakawa Miyako, Asahina Yasuhiro, Kawai-Kitahata Fukiko, Nakagawa Mina, Nitta Sayuri, Otani Satoshi, Nagata Hiroko, Kaneko Shun, Asano Yu, Tsunoda Tomoyuki, Miyoshi Masato, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Tanaka Yasuhito, Iijima Sayuki, Tsuchiya Kaoru, Izumi Namiki, Tohda Shuji, Watanabe Mamoru

Abstract excerpt

Single nucleotide polymorphisms (SNPs) within or near interferon lambda 4 (IFNL4) gene located upstream of IFNL3 are associated with response to anti-HCV therapy both in interferon (IFN)-based and IFN-free regimens. IFNL4 encodes IFNλ4, a newly discovered type III IFN, and its expression is controlled by rs368234815-TT/ΔG, which is in strong linkage disequilibrium (LD) with other tag SNPs within or near IFNL4...

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PMID: 28036111
DOI: 10.1002/jmv.24763

Genes

IFNL3
ISG15
RNF11
SOCS1
SOCS3

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Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.PMID 28036111Read ↗

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