Article

Mineralocorticoid Receptor/Rac1-Driven Podocyte Injury in Fabry Disease: Finerenone and Spironolactone migitate the overactive signaling cascade

2025-10-17

Abstract excerpt

<title>Abstract</title> <p>Podocyte injury is a key driver of Fabry nephropathy (FN), precipitating proteinuria and renal decline. Although mechanisms remain partially elucidated, dysregulated pathways involving mineralocorticoid receptor (MR) activation and Rac1-SGK1 signaling are implicated. This study investigates the role of MR/Rac1/SGK1 signaling and evaluates the nephroprotective potential of MR antagonists...

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Literature Corpus work: 7da06441-9fb4-5ef9-8e3a-68dd0121676e
DOI: 10.21203/rs.3.rs-7674021/v1

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