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Article

Proximal and Distal Nephron-specific Adaptation to Furosemide

2021-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Furosemide, a widely prescribed diuretic for edema-forming states, inhibits sodium reabsorption in the thick ascending limb of the nephron. Tubular adaptation to diuretics has been observed, but the range of mechanisms along the nephron has not been fully explored. Using morphometry, we show that furosemide induces renal tubular epithelial hyperplasia selectively in distal nephron segments. By c...

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Identifiers and source

Literature Corpus work
5899551b-b87e-5385-b497-08ec336a1879
DOI
10.1101/2021.01.12.426306
Open publication

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Proximal and Distal Nephron-specific Adaptation to FurosemideDOI 10.1101/2021.01.12.426306
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