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Article

Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD.

Journal of the American Society of Nephrology : JASN - 1 Nov 2014

Westbrook Lindsey, Johnson Ashley C, Regner Kevin R, Williams Jan M, Mattson David L, Kyle Patrick B, Henegar Jeffery R, Garrett Michael R

Abstract excerpt

Nuclear hormone receptors of the NR4A subgroup have been implicated in cancer, atherosclerosis, and metabolic disease. However, little is known about the role of these receptors in kidney health or disease. Nr4a1-deficient rats (Nr4a1(-/-)) developed on a genetic background susceptible to kidney injury (fawn-hooded hypertensive rat [FHH]) were evaluated for BP, proteinuria, renal function, and metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24722447
DOI: 10.1681/ASN.2013070786
PMCID: PMC4214519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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