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Article

Macula densa-specific NOS1 knockout determines susceptibility to ischemic acute kidney injury.

Clinical science (London, England : 1979) - 15 Apr 2026

Li Minghua, Bahena Lopez Jessica, Ni Runze, Wei Jin, Dhanireddy Kiran, Subramanian Vijay, Wang Lei, Williams Kristof, Hall Nathan, Zheleznova Nadezhda N, Lu Yan, Fu Liying, Lai Enyin, Zhang Jie, McCormick James A, Liu Ruisheng

Abstract excerpt

Acute kidney injury (AKI) causes rapid loss of renal function with high morbidity and mortality. Our previous research showed that neuronal nitric oxide synthase (NOS1) mediates nitric oxide-dependent dilation of the afferent arteriole, inhibiting tubuloglomerular feedback (TGF), which critically regulates single nephron glomerular filtration rate (GFR). This mechanism could affect how vulnerable the organ is to...

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Source

Identifiers

PMID: 41837645
DOI: 10.1042/CS20258807

Genes

NOS1
CD68
CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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