Article
Synuclein alpha accumulation mediates podocyte injury in Fabry nephropathy
2021-12-18
Abstract excerpt
Current therapies for Fabry disease are based on reversing intra-cellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby alleviating lysosome dysfunction. However, their effect in the reversal of endorgan damage, like kidney injury and chronic kidney disease remains unclear. First, ultrastructural analysis of seri...
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Identifiers and source
- Literature Corpus work
- 628c7c2e-b5f3-5bf3-ac39-3006eb1c19ca
- DOI
- 10.1101/2021.12.17.473164