Article
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.
The Journal of biological chemistry - 4 Sept 2015
Amazit Larbi, Le Billan Florian, Kolkhof Peter, Lamribet Khadija, Viengchareun Say, Fay Michel R, Khan Junaid A, Hillisch Alexander, Lombès Marc, Rafestin-Oblin Marie-Edith, Fagart Jérôme
Abstract excerpt
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for the treatment of cardiovascular diseases, they are associated with several side effects....
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