Article
APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease.
The Journal of clinical investigation - 16 Jan 2024
Datta Somenath, Antonio Brett M, Zahler Nathan H, Theile Jonathan W, Krafte Doug, Zhang Hengtao, Rosenberg Paul B, Chaves Alec B, Muoio Deborah M, Zhang Guofang, Silas Daniel, Li Guojie, Soldano Karen, Nystrom Sarah, Ferreira Davis, Miller Sara E, Bain James R, Muehlbauer Michael J, Ilkayeva Olga, Becker Thomas C, Hohmeier Hans-Ewald, Newgard Christopher B, Olabisi Opeyemi A
Abstract excerpt
Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood. Here, we leveraged 3 experimental models and a recently reported small molecule blocker of APOL1 protein, VX-147,...
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